What common issue may arise when handling large bills?

When handling large bills, the most common issue that may arise is the inability to provide change. This occurs frequently in retail and cashier settings where a customer presents a bill that is higher than the total amount of their purchase, particularly if the store does not have enough smaller denominations available in the cash drawer. If a cashier cannot give the correct change back to the customer, it can lead to a frustrating experience for both the cashier and the customer, potentially resulting in lost sales or customer dissatisfaction.

The other options involve various operational challenges, such as misplacing bills, which can happen separately but does not directly relate to the interaction between the cashier and the customer regarding change. Incorrect price scanning is about mistakes in entering or scanning items, which impacts pricing accuracy but not necessarily the handling of large bills. Inaccurate service time pertains to delays in processing transactions, which while important, is not specifically tied to the challenges posed by handling large denominations.